Attention Bias Modification Treatment for Anxious Youth

Not Applicable

Terminated

• Conditions: Generalized Anxiety Disorder; Social Phobia; Separation Anxiety Disorder; Specific Phobia; Obsessive-Compulsive Disorder
• Interventions: Other: Placebo Computer Task; Other: Attention Bias Modification Computer Task

• Registration Number: NCT01979263
• Lead Sponsor: Weill Medical College of Cornell University

Brief Summary

The purpose of this project is to study the feasibility and efficacy of attention bias modification treatment (ABMT) in a randomized-controlled sample of anxious youth.

Detailed Description

The purpose of this study is to determine whether or not ABMT computer-based interventions can be used successfully to help reduce anxiety disorder symptoms in children ages 7 to 17. ABMT is different from most other treatments for anxiety because it is not medication or talk therapy. ABMT is a computerized attention training program designed to change how we direct our attention. The purpose of ABMT is to set in place attentional patterns that do not lead to excessive anxiety. Research has shown that it may be highly effective in reducing anxiety. The Intervention will be composed of your child engaging in 6 brief weekly ABMT sessions. The sessions seem like a repetitive computer game.

This study is appropriate for children who may have symptoms of an anxiety disorder, like Generalized Anxiety Disorder, Separation anxiety Disorder, Social Anxiety Disorder, Specific Phobia, or Obsessive-Compulsive Disorder." Children who appear eligible for the study may attend a diagnostic evaluation and assessment if they meet study criteria.

If a child is eligible for the study, he or she will be randomly assigned to either get an "active" form of the computer program or a "placebo" or inactive form of the computer program. The child will come to six weekly appointments at our clinic that are quite brief, about a half hour. Then the child will have an evaluation after the last of the six appointments to see if the computer intervention was helpful in reducing his or her anxiety. We'd then wait a month and then have a final evaluation to see if the child's anxiety has changed over that period of time.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2013-09-30
• Study Start: 2013-10
• Study First Submitted QC: 2013-11-01
• Study First Posted: 2013-11-08
• Primary Completion: 2017-01-17
• Study Completion: 2017-01-17
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-29
• Last Update Posted: 2019-07-30

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Diagnosis on Anxiety Disorders Interview Schedule for Diagnostic and Statistical Manual-IV Child and Parent versions of Separation Anxiety Disorder, Social Phobia, Specific Phobia, Obsessive-Compulsive Disorder, or Generalized Anxiety Disorder
• Age 7 to 17

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Exclusion Criteria

• Posttraumatic stress disorder or primary diagnosis of major depressive disorder
• Seizure disorder
• Current treatment with psychotropic medication
• Multiple chronic learning disabilities and/or conduct problems

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo Computer Task	Placebo Computer Task	Placebo computer task
Attention Bias Modification	Attention Bias Modification Computer Task	Attention Bias Modification computer task

Primary Outcome Measures

Name	Time	Method
Change in clinical severity ratings on Anxiety Disorder Interview Schedule-Child and Parent Version	after a 6-week intervention and 4-week no-treatment follow-up

Secondary Outcome Measures

Name	Time	Method
Variation in genes associated with treatment response	week 1	We will study allelic variation in a gene that has been associated with treatment response to anxiety interventions, the serotonin-transporter-linked promoter region (5-HTTLPR)

Trial Locations

Locations (2)

New York Presbyterian Hospital--Westchester Division; 🇺🇸 White Plains, New York, United States

Payne Whitney Manhattan Child Division; 🇺🇸 New York, New York, United States