Dissecting Down Syndrome

Withdrawn

• Conditions: Down syndrome; Trisomy 21; 10083624

• Registration Number: NL-OMON42548
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Patients:
- Individuals with Down syndrome caused by an extra, not translocated copy of chromosome 21
- Age 0 - 1 yr
Controls
- Individuals without Down syndrome and a non-hereditary disorder fo which blood sampling is needed
- Age 01- yr

Exclusion Criteria

Individual with Down syndrome with a major malformation.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Significant differences in DNA-methylation- and genetranscription profiles<br /><br>between controls and DS individuals.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>None. </p><br>