Down's syndrome in children males – biochemical characterisations in different media using non-randomised trial and systematic study
- Conditions
- MedDRA - DOWN SYNDROME
- Registration Number
- DRKS00014074
- Lead Sponsor
- Department of Basic Sciences, Faculty of Dental Medicine, Damascus University, Main Highway, AlMazaa, Damascus, Syria
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 145
Males, children, Permanent residences in Damascus, Living far from plaster dust sources of any possible adjacent construction sites and far from the industrial zone (incl. concrete plants), Non-smokers (all kinds of tobacco), Non-smoker families, Unstimulated saliva samples, Controls were healthy and non-diabetic young individuals, Controls had no systemic diseases or any local infection before 3 months and did not also take any medication for at least 3 months before sample collection, DS children patients were trisomy 21 diagnosed by karyotype test and assessed by clinical examination. Patients were euthyroid at the time of study as their thyroid-stimulating hormone (TSH) and free thyroxine hormone (FT4) were within the normal range.
Females, Male smokers, Smoker families, Systemic diseases, Participant takes medication for at least 3 months, Children with congenital oligodontia and delayed eruption (more than 1yr), Individuals with the history of antibiotics, anticholinergic, antihistaminic and antipsychotic therapy two weeks prior to sample collection, intervened medications that could get in the way with ions metabolisms such as taking vitamin D, aspirin, or herbal medicine which can easily interfere for instance with Fe metabolism. In addition, candidates with concentrations of thiocyanate higher than 80 mg SCN-/L (1 mg SCN-/L =17.2 µM SCN-/L) saliva or 3.00 mg SCN-/L serum were excluded from the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method