Abnormal immune system in Down syndrome: allergic sensitization and hepatitis B vaccination status 2 - blood sample
- Conditions
- downsyndroomDown syndrometrisomy 2110027665
- Registration Number
- NL-OMON40983
- Lead Sponsor
- Jeroen Bosch Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 580
Inclusion Criteria
Down syndrome; 2 years of age or older; planned venepuncture.
Exclusion Criteria
No informed consent; participation in the All-HBV-DS1-leftover serum study (study on the same subject, but leftover serum is used for the tests). In each participant the tests will only be performed once.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Percentage of people with at least one allergen specific IgE with a<br /><br>concentration of >= 0,35 kU/l; the percentage of people with a protective titer<br /><br>against HBV (anti-HBs-titer >=10 IE/l).</p><br>
- Secondary Outcome Measures
Name Time Method <p>The concentration of total IgE, the concentration of specific IgE*s in the<br /><br>inhalation antigen and food antigen mix, the relation between age and<br /><br>sensitization and between sensitization, allergy related symptoms and the<br /><br>performance of diagnostic tests and/or treatments and the percentage of people<br /><br>with elevated total IgE. The level of the HBV titer (anti-HbS).</p><br>