Dexamethasone Plus Bupivacaine Versus Bupivacaine in Bilateral Trans-incisional Paravertebral Block in Lumbar Spine Surgeries, a Randomized Clinical Trial.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- First time to analgesic requirement
研究概览
简要总结
The purpose of this study is to compare addition of dexamethasone to bupivacaine versus bupivacaine alone for trans-incisional bilateral paravertebral block for postoperative analgesia in elective lumbar spine surgeries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •physical status American Society of Anesthesiologists (ASA) I or II.
排除标准
- •refuse to participate have a body mass index (BMI) >30 kg/m2 ASA physical status >II have major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological) coagulation abnormalities infection at the injection site tumor in the paravertebral space sepsis Severe chest deformity or scoliosis, due to the possibility of injection into the meninges an allergy or contraindications to the drugs used in the study uncontrolled diabetes patients with active gastric ulceration a history of drug addiction or alcohol abuse a psychiatric illness mental retardation interfering with the evaluation of pain scores.
研究组 & 干预措施
Dexamethasone + bupivacaine in bilateral TiPVB in lumbar spine surgery
Dexamethasone plus bupivacaine in bilateral trans-incisional paravertebral block in lumbar spine surgery for postoperative analgesia
干预措施: Dexamethasone+ Bupivacaine (Drug)
Bupivacaine in bilateral TiPVB in lumbar spine surgery
Bupivacaine in bilateral trans-incisional paravertebral block in lumbar spine surgery for postoperative analgesia
干预措施: Bupivacaine (Drug)
结局指标
主要结局
First time to analgesic requirement
时间窗: 1st 24 hour
After extubation, an IV PCA system will be connected to the patient (Accufuser Plus® 100 mL: Woo Young Medical Co, Korea). PCA will be prepared with 60 mL of normal saline containing 60 mg of morphine, and the system will be programmed to give a 0.5 mL bolus dose with a lockout interval of 8 min. basal rate will not be present. PCA will be discontinued at 24 h after surgery, and at that time, oral analgesics begin.
次要结局
- Total opioid consumption .(1st 24 hour)
- Visual analogue scale (VAS)(1st 24 hours postoperatively)
研究者
Amin Mohammed Alansary Amin Ahmed Helwa
Assistant professor
Ain Shams University