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临床试验/NCT04631822
NCT04631822已完成不适用

Comparative Study Between Dexamethasone, and Dexmedetomidine as Additives to Bupivacaine in Ultrasound Guided Adductor Canal Block in Knee Arthroscopy

Rasha Hamed2 个研究点 分布在 1 个国家目标入组 135 人开始时间: 2021年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
135
试验地点
2
主要终点
Dynamic Visual Analogue Scale score

研究概览

简要总结

a comparison shall be conducted between dexamethasone accompanied by bupivacaine, on one hand, and dexmedetomedine accompanied by bupivacaine on the other hand and a control group for pain-free knee arthroscopic surgeries.

详细描述

Arthroscopic knee surgery can cause significant postoperative pain to the degree that can potentially delay timely discharge from the ambulatory surgical setting. Analgesia after knee surgery can be provided by multiple, non-systemic, non-opioid-based methods, including local anesthetic infiltration, peripheral nerve blockade, neuraxial procedures, and intra-articular injections. The femoral nerve block has been shown to be superior to traditional intra-articular injection of local anesthetics in some knee surgeries, but motor blockade of the quadriceps muscle, with the potential risk for falls, limits the value of femoral blocks for less invasive ambulatory surgery. Orthopedic surgery is increasingly being performed on an ambulatory basis, where perioperative analgesia can improve timely discharge in the outpatient setting.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
19 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patients of aged more than 18 years old ASA "American Society of Anaesthesia"
  • physical status I or II under-going any unilateral knee arthroscopy.

排除标准

  • patient refusal.
  • Pre-existing pain ; postoperative pain similar to preoperative pain
  • Known contraindications to peripheral nerve block, including local skin infections, bleeding diathesis, and coagulopathy.
  • Allergies to local anesthetics, dexmedetomidine, or any component of multimodal analgesia.

结局指标

主要结局

Dynamic Visual Analogue Scale score

时间窗: month 1 postoperative

a scale of 11 points. 0 = no pain, 10=worst pain

次要结局

  • month 3 opioid analgesia(month 3 postoperative)
  • 24 hours opioid analgesia consumed(24 hours postoperative)
  • Visual Analogue Scale score(24 hours postoperative)
  • Dynamic Visual Analogue Scale score(month 3 postoperative)

研究者

发起方
Rasha Hamed
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Rasha Hamed

Rasha Hamed

Assiut University

研究点 (2)

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