NL-OMON42359撤回2 期
The physiology of glucagon-like peptide-1 receptor expression in patients with endogenous hyperinsulinism: correlation with histopathology - GLP-1-CHI
ucleaire geneeskunde en radiologie0 个研究点目标入组 10 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 17（—）
入选标准
- •Biochemically and clinically proven endogenous congenital hyperinsulinism:
- •- Unresponsive to medical treatment (diazoxide)
- •- Indication for 18F-DOPA PET/CT based on mutation analysis
- •Standard imaging (18F-DOPA PET/CT) not older than 8 weeks
- •<16 years old
- •Informed consent signed by parents or legal guardians of the patient.
排除标准
- •Genetically proven diffuse CHI (presenting with a homozygous or compound heterozygous ABCC8/KCNJ11 mutation)
- •Calculated creatinine clearance below 40 ml/min
- •Evidence of other malignancy than insulin producing tumors in conventional imaging (suspicious liver, bone and lung lesions based on CT)
- •Age > 16 years
- •No signed informed consent
研究者
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