NL-OMON46337尚未招募2 期
The physiology of glucagon-like peptide-l receptor expression in patients with endogenous hyperinsulinism: correlation with histopathology - Exendin-CHI
ucleaire geneeskunde en radiologie0 个研究点目标入组 5 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 5
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 17（—）
入选标准
- •- Biochemically and clinically proven endogenous congenital hyperinsulinism:
- •- Unresponsive to medical treatment (diazoxide)
- •- Indication for 18F-DOPA PET/CT based on mutation analysis
- •- Standard imaging (18F-DOPA PETICT) not older than 8 weeks
- •- <16 years old;- informed consent signed by parents or legal guardians of the patient.
排除标准
- •- Genetically proven diffuse CHI (presenting with a homozygous or compound heterozygous ABCCS/KCNJ11 mutation)
- •- Calculated creatinine clearance below 40 ml/min
- •- Evidence of other malignancy than insulin producing tumors in conventional imaging (suspicious liver, bone and lung lesions based on CT)
- •- Age >16 years
- •- No signed informed consent
研究者
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