Modulation of Visual-Spatial Learning in Patients With Mild Cognitive Impairment (MCI) by tDCS
- Conditions
- Mild Cognitive Impairment (MCI)
- Interventions
- Device: tDCSBehavioral: training
- Registration Number
- NCT02110043
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement in learning and memory in patients with mild cognitive impairment (MCI) and to examine the underlying neuronal mechanism.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
Not provided
- severe internal or psychiatric disease
- epilepsy
- other severe neurological diseases, e.g. previous major stroke or brain tumor
- DMS-IV manifest dementia
- contraindication for MRT (claustrophobia, metallic implants, tattoos)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description training + tDCS tDCS Combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) training + sham stimulation tDCS Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation training + tDCS training Combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) training + sham stimulation training Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation
- Primary Outcome Measures
Name Time Method Performance in LOCATO task (Visual-spatial learning and memory) after a combination of intensive visual-spatial training and tDCS immediately after end of a 3-day period of training in tDCS condition vs sham condition Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to improvement of visual-spatial learning and memory measured by performance in LOCATO task after end of a 3 day period of training compared to sham stimulation.
- Secondary Outcome Measures
Name Time Method long term effects after 1 month vs baseline long term effects measured by performance in LOCATO task in tDCS condition after end of cognitve training and after 1 month compared to control conditions
functional changes: Connectivity end of 3-day cognitive training vs baseline Connectivity (measured by resting-state fMRT and correlation analysis) at baseline compared to end of 3 day period of training
cortical excitability at baseline cortical excitability measured by transcranial magnetic stimulation (TMS)
Quality of Life after 1 month vs baseline quality of life as measured by standardized questionaire at baseline compared to quality of life measured 1 month after intervention (training and stimulation vs. training and sham-stimualtion)
memory immediately after end of 3-day of cognitive training, after 1 month vs. baseline memory performance tested at baseline compared to memory performance after the end of a 3-day cognitive training period and after 1 month (posttraining) in training and stimulation vs. training and sham stimulation
affective state immediately after the end of 3-day cognitive training, after 1 month vs. baseline affective state measured at baseline compared to affective state measured after the end of a 3-day cognitve training period and after 1 month (posttraining) in training and stimulation vs. training and sham stimulation
genotyping of learning related polymorphisms once To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed (i.e., APOE, BDNF Val66Met, COMT Val158Met).
Trial Locations
- Locations (1)
Charite Universitätsmedizin Berlin
🇩🇪Berlin, Germany