Brain Imaging of Pain Phenotype and Genotype With Novel Scanning Techniques
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- University of Pittsburgh
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Areas of brain activity from a transcutaneous painful stimulation
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
This study has two purposes: first, to locate and identify the "brain activation" (the areas of the brain) which respond to pain; and second, to look at how brain activation is influenced by a person's genetics (the traits they inherited from their parents). A Magnetic Resonance Imaging (MRI) scanner will be used to gather pictures of the brain (similar to an x-ray, but based on different scientific principles) that will be used to determine which areas are active. The hypothesis is that the variation in brain activity between people can be partially explained by genetic differences. This study consists of an two pain tasks applied during a one time visit to the MRI suite. There are no followup visits.
Investigators
Jim Ibinson
MD, PhD
University of Pittsburgh
Eligibility Criteria
Inclusion Criteria
- •Age 18 to 50
- •Right-handed
- •Male or female
- •Healthy individuals not taking any medication.
Exclusion Criteria
- •Pregnancy
- •Diagnosed with any treated or untreated medical or neurological conditions
- •Using any prescription drugs, including antidepressants, pain medications, sedative medications, blood pressure medications, seizure medications, or antipsychotics. Oral contraceptives are permitted
- •Using any over-the-counter medications including aspirin, Tylenol, or herbal supplements
- •Using any illicit substances
- •Contraindications to magnetic resonance imaging.
Outcomes
Primary Outcomes
Areas of brain activity from a transcutaneous painful stimulation
Time Frame: At the conclusion of the 1 hour scanning session; Visit one
A nerve stimulator will be turned on at the level that causes you to report 7/10 pain for 30 seconds, followed by a 30 second period of rest. This will be repeated four times. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
Areas of brain activity from a 45 minutes Capsaicin cream application
Time Frame: At the conclusion of the 1 hour scanning session; Visit 1
The painful stimulation will now be caused by placing a piece of gauze soaked with capsaicin, the active ingredients in chili peppers, on the subject's right arm. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
Secondary Outcomes
- Pain phenotyping(After the 45 minute Capsaicin cream application; Visit 1)