Brain and Genetic Predictors of Individual Differences in Pain and Analgesia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain, Acute
- Sponsor
- Trustees of Dartmouth College
- Enrollment
- 541
- Locations
- 1
- Primary Endpoint
- Pain Rating Scores Made on a Visual Analog Scale (VAS)
- Status
- Completed
- Last Updated
- 11 months ago
Overview
Brief Summary
The purpose of the study is to gain a better understanding of pain processing in the brain. Our understanding of how pain is processed in the brain is limited. We are testing for individual differences in pain perception and emotion.
Investigators
Tor Wager
Director, Cognitive and Affective Neuroscience Laboratory; Professor, Department of Psychology and Neuroscience and the Institute for Cognitive Science
University of Colorado, Boulder
Eligibility Criteria
Inclusion Criteria
- •Participants must be registered in the Colorado Community Twin Sample (CTS).
Exclusion Criteria
- •Not being registered in the Colorado Community Twin Sample (CTS).
- •Any MRI contraindications.
Outcomes
Primary Outcomes
Pain Rating Scores Made on a Visual Analog Scale (VAS)
Time Frame: Measured during pain tasks at a single 4 hour experimental session (within one month of screening completion).
Self reported pain using a Visual Analogue Scale (VAS) ranging from 0-100 (with 0 representing "no pain at all" and 100 representing "most intense pain imaginable (in the context of the experiment)). Higher scores indicate more pain. 0 is the minimum value and 100 is the maximum value. This scale is used for both thermal and mechanical pain. Reported values reflect averages of VAS ratings for individual stimuli for each of thermal and mechanical pain.