Contribution of End-Tidal Carbon Dioxide and Integrated Pulmonary Index Monitoring With Capnography to Diabetic Ketoacidosis Diagnosis and Management
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Correlation between PCO2 and EtCO2
研究概览
简要总结
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
详细描述
Purpose: In this study, the contribution of this non-invasive follow-up method to the management of DKA and the reduction of the frequency of invasive procedures was investigated in patients diagnosed with diabetic ketoacidosis (DKA) in the pediatric emergency department and followed up with capnography
Method: This study is a prospective clinical study. Between October 2020- November 2022, EtCO2 and IPI follow-up of 0-18 year-old pediatric patients diagnosed with DKA in the Pediatric Emergency Service of Akdeniz University Medical Faculty Hospital was performed by capnography. DKA diagnosis, grading, clinical follow-up and treatment termination criteria of the patients were determined according to the ISPAD 2018 Diagnosis and Treatment Guidelines. In the study; During the clinical follow-up, changes in GCS, blood glucose, vital, blood gas and capnograph parameters were examined. Demographic data were analyzed in all patients and in groups of patients who underwent DKA grading. GCS, blood gas and capnograph parameters were compared in the patient groups with DKA grading. Diagnostic test performances of blood gas and capnograph parameters were compared to detect low GCS
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Days 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The study group consisted of pediatric patients aged 0-18 years who were diagnosed with Diabetic Ketoacidosis and applied to Akdeniz University pediatric emergency department.
- •Written consent was obtained.
排除标准
- •Who did not give written consent were not included in the study.
结局指标
主要结局
Correlation between PCO2 and EtCO2
时间窗: 2 days
The positive linear correlation between PCO2 and EtCO2 indicates that acidosis can be monitored with EtCO2.
Correlation between Integrated Pulmonary Index and degree of acidosis
时间窗: 2 days
Detection of a positive linear correlation between those with Integrated Pulmonary Index \<8 and the degree of acidosis
Prediction of cerebral edema with Integrated Pulmonary Index
时间窗: 2 days
Detection of significant decrease in Glasgow Coma Scale (GCS\<13) in patients with Integrated Pulmonary Index \<4
次要结局
未报告次要终点
研究者
Ozlem Tolu Kendir
Assoc. Prof.
Akdeniz University