Ecg & Echo Changes in Children With DKA

• Conditions: Pediatric Disorder

• Registration Number: NCT03454152
• Lead Sponsor: Assiut University

Brief Summary

Diabetic ketoacidosis (DKA) is an important complication of childhood diabetes mellitus and the most frequent diabetes-related cause of death in children.

Diabetic ketoacidosis (DKA) is caused by a decrease in effective circulating insulin associated with increases in counter regulatory hormones including glucagon, catecholamines, cortisol, and growth hormone. This leads to increased glucose production by the liver and kidney and impaired peripheral glucose utilisation with resultant hyperglycaemia, and hyperosmolality. Increased lipolysis, with ketone body (beta-hydroxybutyrate, acetoacetate) production causes ketonaemia and metabolic acidosis. Hyperglycaemia and acidosis result in osmotic diuresis, dehydration, and obligate loss of electrolytes.

Detailed Description

DKA can affect cardiovascular function through several mechanisms. The effect of acidosis on the heart depends upon the pH level. In mild acidosis, there is increased catecholamine release which is compensated by increased inotropy, chronotropy, cardiac output and peripheral vascular resistance. When acidosis is severe, i.e. pH is less than 7.2, the H+ ions have a direct cardiac depressant action.

Fluid and electrolyte imbalance is very common in DKA, Potassium deficit is one of the most important of electrolyte imbalances seen in DKA as it can lead to fatal arrhythmias. The most common and perhaps the earliest ECG finding in hypokalemia is a prominent U wave, usually evident in leads II and III. The most common cardiac arrhythmias are atrial premature contractions, atrial tachycardia with or without atrioventricular block, supraventricular and ventricular premature contractions.

Study Timeline

• Study First Submitted: 2018-02-18
• Status Verified: 2018-03
• Study First Submitted QC: 2018-03-02
• Last Update Submitted: 2018-03-02
• Study First Posted: 2018-03-05
• Last Update Posted: 2018-03-05
• Study Start: 2019-03
• Primary Completion: 2020-03
• Study Completion: 2020-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Pediatric patients aged : 1 month -18years with diabetic ketoacidosis

Read More

Exclusion Criteria

• Pediatric Patients who have associated cardiovascular disease. ( congenital or rheumatic).
• Pediatric patients with hyperglycemic hyperosmolar state.
• Pediatric patients with other causes of metabolic acidosis.

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Echocardiography parameters	baseline	Right and left ventricular dimension during diabetic ketoacidosis and after correction.
Electrocardiogram parameters	baseline	QT interval and PR interval.

Secondary Outcome Measures

Name	Time	Method
Electrocardiogram changes	baseline	ST segment elevation or depression
Echocardiography findings	baseline	Systolic and diastolic left ventricular function