Fever with special emphasis on Central fever in a traumatic brain injury patients admitted in Trauma ICU: A Prospective Cohort study

This study will be conducted in department of Anaesthesiology,IMS,BHU,Varanasi after obtaining written and informed consent and institutional ethical approval.After CTRI registration, patients fulfilling inclusion criteria will be included in this study and will be further evaluated by sending laboratory investigations and analyzing the clinical parameters. Demographic data and empirical antibiotics in use on patient will also be recorded. Various laboratory investigations include Complete blood count , C- reactive protein, chest X-ray , pro calcitonin levels and culture . Patients having positive culture reports will be classified as infectious fever and antibiotic escalation/deescalation will be done based on sensitivity report. Patients with negative culture report will be further evaluated to identify various other causes of fever and will be classified separately to calculate the incidence of various causes of fever . Patients included under neurogenic fever will be further evaluated and all the relevant clinical data from the onset of fever will be collected .This will include medical history , presenting symptoms and result of diagnostics tests.

Based on objective of study , descriptive and inferential statistics will be drawn to determine the association of provided variables with neurogenic fever and a comprehensive list of variables will be formulated . This list will consists of variables that demonstrate high diagnostic accuracy for Central fever .