Lung and Diaphragm Ultrasound Evaluation During Weaning From Mechanical Ventilation in COVID-19 Patients：A Prospective, Observational Study

Second Affiliated Hospital, School of Medicine, Zhejiang University1 site in 1 country35 target enrollmentJanuary 11, 2023

ConditionsWeaning COVID-19 Lung Ultrasound Diaphragm Ultrasound

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Weaning
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Enrollment: 35
Locations: 1
Primary Endpoint: The primary end-point was to verify the lung and diaphragm ultrasound evaluation if the predicts weaning success/failure from mechanical ventilation
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this observational study is to learn about the function of lung and diaphragm ultrasound during weaning from mechanical ventilation in COVID-19 patients. The aim of this study was that the lung ultrasound score and diaphragm muscle mobility could be a potential predictive factor of weaning success.

Registry

clinicaltrials.gov

Start Date

January 11, 2023

End Date

March 30, 2023

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•age \> 18 years,
•critically ill patients with COVID-19 (defined as those requiring mechanical ventilation due to respiratory failure), and eligible for their first SBT according to the attending physician's judgement that the underlying disease which led to intubation had sufficiently resolved.

Exclusion Criteria

•patients with previous cardiothoracic surgery or pleurodesis and patients who presented with stridor (due to upper airway involvement) as a cause of extubation failure
•neuromuscular disease

Outcomes

Primary Outcomes

The primary end-point was to verify the lung and diaphragm ultrasound evaluation if the predicts weaning success/failure from mechanical ventilation

Time Frame: spontaneous-breathing trial started until 48 hours following extubation

Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation

Secondary Outcomes

The secondary outcome was to verify the predictive value of the traditional weaning parameters(spontaneous-breathing trial started until 48 hours following extubation)