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Clinical Trials/NCT03557905
NCT03557905
Completed
Not Applicable

Ultrasonographic Assessment of Lung Recruitment Maneuvers in Pediatric Patients Undergoing Lengthy Microsurgery Operations

Assiut University1 site in 1 country44 target enrollmentAugust 6, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Intraoperative Complications
Sponsor
Assiut University
Enrollment
44
Locations
1
Primary Endpoint
Lung Areation Score
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

The aim of this study will be to explore the clinical value of ultrasonic monitoring in the diagnosis of anesthesia-induced atelectasis, the assessment of the effects of lung recruitment, the best positive end-expiratory pressure (PEEP) after RM and in the detection of the point of lung re-collapse after RM in pediatric patients undergoing lengthy microsurgery operations using two levels of intraoperative FIO2 (0.5 VERSUS 0.3).

Detailed Description

* To maximize the benefits, minimize the drawbacks and assess the adequacy of the recruitment maneuver; adequate monitoring at the bedside is essential. Several methods have been proposed, including measuring end-expiratory lung volume or pulmonary compliance, volumetric capnography, oxygenation indices, electrical impedance tomography, computerized tomography and lung ultrasound. * For lung CT examination patients must be transported out to the radiation unit, which carries risk of transfer, high cost, and radiation exposure. The oxygenation method which is the most commonly used, but it is necessary to repeat arterial blood collection many times, which is cumbersome and expensive. * Using lung ultrasound (LUS) as real-time guidance during the recruitment maneuver has gained popularity recently owing to its' easy applicability and non-invasive nature. Sonography is a radiation-free methodology which plays an important role in diagnosing pulmonary diseases in children, including obstructive and compressive atelectasis of different origins. Furthermore, lung ultrasound has shown reliable sensitivity and specificity for the diagnosis of anaesthesia-induced atelectasis in children. * LUS can identify children needing a recruitment maneuver to re-expand their lungs and help optimize ventilator treatment during anesthesia.

Registry
clinicaltrials.gov
Start Date
August 6, 2018
End Date
January 30, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Hala Saad Abdel-Ghaffar

Professor of anesthesia and intensive care, faculty of medicine, Assiut university.

Assiut University

Eligibility Criteria

Inclusion Criteria

  • Age: 2-12 years old.
  • ASA physical status classification I-II.
  • Undergoing lengthy microsurgery operations
  • and requiring endotracheal intubation and mechanical ventilation for more than 4 hours.-

Exclusion Criteria

  • ASA Physical status classification \>II.
  • Thoracic or abdominal surgery.
  • Preexisting lung disease.
  • Pre-operative chest infection or abnormal chest US findings.
  • Cardiac patients.-

Outcomes

Primary Outcomes

Lung Areation Score

Time Frame: 10 minutes after induction of anesthesia

lung Areation Score calculated on first lung ultrasound.For a given thoracic area, points will be allocated to the worst LUS pattern observed and video clips of each region examined will be stored. The sum of the points obtained in all the 12 lung areas will define the LUS aeration score, ranging from 0 to 36 for the whole thorax. This score is inversely proportional to the degree of lung aeration.

Study Sites (1)

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