Role of Lung Ultrasound In Assessment Of Recruitment Maneuvers In Ventilated Preterms With Respiratory Distress Syndrome and Its Correlation With Tracheal IL-6 Level
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Lung ultrasound guided recruitment maneuver and the total number of NICU admission days.
研究概览
简要总结
This work is designed to:
- Evaluate the efficacy of lung ultrasonography in detecting opening and closing lung pressures in ventilated preterm neonates with respiratory distress syndrome.
- Determine the efficacy of lung ultrasonography in optimizing lung volume and its correlation with pulmonary inflammatory reaction as evidenced by IL-6 level in tracheal aspirate.
详细描述
The studied population included 44 preterm infants. Anthropometric measurements, gestational age, sex, mode of delivery, maternal disease and Apgar score were found to be matched in the two studied groups indicating successful randomization as seen in these balanced demographic variables between the groups.
The studied population included 44 preterm infants. Then they were allocated randomly to one of 2 groups in order by admission:
Group A: included 22 patients on whom the recruitment maneuver was applied guided by lung ultrasonography.
Group B: included 22 patients on whom the recruitment maneuver was not ultrasound guided. This is considered the control group.
Anthropometric measurements, gestational age, sex, mode of delivery, maternal disease and Apgar score were found to be matched in the two studied groups indicating successful randomization as seen in these balanced demographic variables between the groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 1 Hour 至 2 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gestational age ≤ 36 weeks.
- •In need for invasive mechanical ventilation for RDS according to Downes Score .
排除标准
- •excluded:
- •Major upper or lower airway anomalies.
- •Significant congenital anomalies including cardiac, abdominal or respiratory.
- •Surgical cases
- •Inborn errors of metabolism
- •Early onset sepsis.
- •Meconium aspiration syndrome.
- •Hypoxic ischemic encephalopathy.
结局指标
主要结局
Lung ultrasound guided recruitment maneuver and the total number of NICU admission days.
时间窗: 1 year
The relation between early lung recruitment maneuver guided by lung ultrasound and how many days requiring admission in the NICU .
Lung ultrasound and recruitment maneuver
时间窗: 1 year
An ultrasound re aeration score is calculated from changes in the ultrasound pattern of each region examined during the recruitment maneuver (N,B1,B2,C).
Lung ultrasound guided recruitment maneuver and the period of oxygen dependency.
时间窗: 1 year
The relation between early lung recruitment maneuver guided by lung ultrasound and how many days requiring oxygen therapy in the NICU .
Lung ultrasound and diagnosis of respiratory distress syndrome
时间窗: 1 year
Forty four preterm neonates diagnosed with respiratoey distress syndrome had lung ultrasound assessment . Its grading was N=normal (presence of lung sliding with A lines or fewer than two isolated B lines) , B1=multiple well-defined B lines , B2=multiple coalescent B lines , C=Consolidation.
Lung ultrasound guided recruitment maneuver and its relation to lung inflammation
时间窗: 1 year
Tracheal aspirate IL-6 is measured initially before recruitment maneuver, and on the third day if still ventilated ,or before extubation if done earlier than the third day.
次要结局
未报告次要终点
研究者
Dina Reda Fikry Kamel
Assistant Lecturer
Ain Shams University