ocalizing the eloquent cortex in children with epilepsy: Development and validation of a child-friendly fMRI protocol

Completed

• Conditions: epilepsy; 10039911

• Registration Number: NL-OMON46983
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 78

Inclusion Criteria

Pilot phase and phase 2:
- Healthy subjects (m/f)
- Age 6-10;Phase 3:
- Epilepsy patients (m/f) scheduled for epilepsy surgery
- Age 6-10 or older with a mental age equivalent to this age range. The patients neurologist/neuropsychologist will decide whether older patients meet this criteria by evaluating the results of the patients neuropsychological assessment which includes IQ testing with for example the WPPSI-III-NL or WISC-III-NL. These tests are part of the clinical examination procedures and are performed by all epileptic patients who might require surgery

Exclusion Criteria

- Metal objects in the body that are not MRI compatible
- Anxiety in the scanner (evaluated by parent/caretaker, or after practice in mock scanner)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Similarity amongst fMRI activation patterns of healthy controls<br /><br>- Match between fMRI activation pattern and standard diagnostic results in<br /><br>epilepsy patients</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NVT</p><br>