Flurbiprofen Axetil and Nalbuphine for Postoperative Pain and Discomfort After Orbital Decompression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Pain after orbital decompression
研究概览
简要总结
The purpose of this study is to evaluate the postoperative pain and discomfort using flurbiprofen axetil or nalbuphine administration after orbital decompression under general anesthesia.
详细描述
To investigate postoperative analgesia achieved with intraoperative administration of intravenous nalbuphine and flurbiprofen axetil in patients undergoing orbital decompression
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •16-75 years old
- •diagnosed as thyroid eye disease
- •bone removal orbital decompression under general anesthesia
- •American Society of Anesthesiologists (ASA) physical status of I-II
排除标准
- •body mass index (BMI) <18.5 or >35
- •any uncontrolled clinical problems
研究组 & 干预措施
flurbiprofen axetil
flurbiprofen axetil intraoperative administration 100mg
干预措施: Flurbiprofen Axetil (Drug)
nalbuphine
nalbuphine intraoperative administration 0.1mg/kg
干预措施: Nalbuphine (Drug)
nalbuphine and flurbiprofen axetil
flurbiprofen axetil intraoperative administration 100mg and nalbuphine intraoperative administration 0.1mg/kg
干预措施: Nalbuphine and Flurbiprofen Axetil (Drug)
结局指标
主要结局
Pain after orbital decompression
时间窗: 24 hour after recovery
Pain levels measured using Numerical Rating Scale (NRS) ranging from 0 to 10, where 0 represents no pain and 10 represents the worst pain imaginable ; this scale has been confirmed to be sensitive and reliable.Clinically significant postoperative pain was considered serious pain (NRS score ≥5).
次要结局
- Discomfort after orbital decompression(24 hour after recovery)
研究者
Huijing Ye
Principal Investigator
Sun Yat-sen University