跳至主要内容
MedPath Trial logoMedPath TrialMedPath Trial Home
临床试验/ISRCTN52682983
ISRCTN52682983进行中（未招募）未知

IntraCerebral Haemorrhage: Imaging Microglial Activation and blood­brain barrier leakaGE (IMAGE-ICH) - an observational cohort study

niversity of Manchester (UK)0 个研究点目标入组 55 人开始时间: 2015年10月22日最近更新:
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
适应症

试验速览

阶段
未知
状态
进行中（未招募）
发起方
入组人数
55
研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

暂无简介。

研究设计

研究类型
Observational

入排标准

性别
All

入选标准

  • •1. Age 18 or over
  • •2. Acute, spontaneous, supratentorial ICH within 24 h of symptom onset
  • •3. Glasgow coma scale (GCS) score = 9
  • •4. Research MR scan can be performed within 3 days of symptom onset
  • •Additional inclusion criteria for PET imaging (d 2­7):
  • •5. GCS = 14
  • •6. Able to transfer from chair to bed with assistance of two people
  • •7. Deemed medically stable by medically­ qualified researcher for transfer to Wolfson Molecular Imaging Centre (WMIC) on day of PET scan

排除标准

  • •1. Contraindication to magnetic resonance (MR) scanning
  • •2. Pre-existing ­brain lesion (e.g. tumour, previous stroke) that is likely to interfere with the planned analysis
  • •3. ICH known or strongly suspected of being secondary to a structural vascular malformation (e.g. cerebral aneurysm, arteriovenous malformation, cavernoma, dural arteriovenous fistula), tumour, haemorrhagic transformation of an ischaemic stroke, or venous sinus thrombosis
  • •4. Clear history of recent (<7 days prior to onset) head trauma, thought to be the cause of intracerebral haemorrhage
  • •5. Any known inflammatory disease which in the opinion of the PI may interfere with interpretation of the study results
  • •6. Known, uncorrected bleeding disorder
  • •7. Female patient who may be pregnant or who is breastfeeding
  • •8. Significant renal impairment (estimated glomerular filtration rate < 30)
  • •9. Any other significant disease or disorder which, in the opinion of the PI or his delegatee, may put the participant at risk
  • •because of participation in the study, or may influence the result of the study, or the participant’s ability to participate in the study
  • •10. Neurosurgical procedure performed since admission or booked for surgery
  • •11. Treatment with drugs known to or likely to interfere with PK11195 binding (including benzodiazepines, steroids, minocycline) that cannot be stopped in sufficient time to prevent interference with PET scanning

研究者

发起方
niversity of Manchester (UK)

相似试验

招募中
不适用
MRI brain imaging in spontaneous intracerebral haemorrhage; pinpointing the underlying vascular disease
NL-OMON44852niversitair Medisch Centrum Utrecht221
已完成
不适用
EVACUATE-pilot - Ultra-Early, minimally inVAsive intraCerebral haemorrhage evacUATion versus standard trEatment (EVACUATE)-Pilot phaseStroke - Haemorrhagicstroke
ACTRN12619001748101royal adelaide hospital14
终止
不适用
New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid StenosisStroke, IschemicCarotid AtherosclerosisCarotid Artery Stenosis
NCT03764306Jagiellonian University31
已完成
2 期
'SPOT Sign' seLection of Intracerebral haemorrhage to Guide Haemostatic therapyIntracerebral hemorrhage (ICH)Circulatory SystemIntracerebral hemorrhage
ISRCTN29749408Sunnybrook Research Institute (Canada)110
招募中
不适用
A study of neuroimaging indicators documented in healthy adultsDiseases of the nervous system
KCT0000214Seoul National University Hospital2,000