MRI brain imaging in spontaneous intracerebral haemorrhage; pinpointing the underlying vascular disease - FETCH: Finding the ETiology in spontaneous Cerebral Haemorrhage

niversitair Medisch Centrum Utrecht0 个研究点目标入组 221 人开始时间: 待定最近更新: 2024年4月29日

试验速览

暂无简介。

•For substudy A - 3T unenhanced MRI scanning:
•- Age >= 18 years
•- ICH confirmed by CT
•- 3T MRI scanning possible preferably within 10 days, but at least within 3 months of ICH diagnosis
•- No obvious cause of ICH (tumor, vascular anomaly or trauma as cause of haemorrhage);For substudy B - 7T gadolinium enhanced MRI scanning:
•- Participants of substudy A
•- 7T MRI scanning possible preferably within 10 days, but at least within 3 months of ICH diagnosis;For substudy C - CT spot sign study:
•- Age >= 18 years
•- ICH confirmed by CT
•- CTP and CTA has been performed on admission
•- Non contrast CT possible within 48 hours after symptom onset.
•- No obvious cause of ICH (tumor, vascular anomaly or trauma as cause of haemorrhage)

•For substudy A - 3T unenhanced MRI scanning:
•- Contraindications for MR imaging (see appendix A research protocol) ;For substudy B - 7T gadolinium enhanced MRI scanning:
•- Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body).
•- Known prior allergic reaction to gadolinium contrast or one of the constituents of its solution for administration.
•- Severely impaired renal function (severe renal insufficiency, GFR <30 ml/min/1.73 m; or nephrogenic systemic fibrosis / nephrogenic fibrosing nefropathy (NSF/NDS))
•- Pregnancy;For substudy C - CT spot sign study:
•- Pregnancy ;For all studies:
•- No informed consent obtained from patient or legal representative

发起方

niversitair Medisch Centrum Utrecht