The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Farwaniya Hospital
- Enrollment
- 5
- Locations
- 2
- Primary Endpoint
- Size of corneal perforation
Study Overview
Brief Summary
Case series of 5 ICU patients in Farwaniya Hospital who developed exposure keratitis and a subsequent small corneal perforation between April 2022 and April 2024.
The investigators highlight the non-surgical role of OmniLenz® in the treatment of small corneal perforations secondary to exposure keratitis. The inclusion criteria were corneal perforation less than 1mm in size, positive culture & sensitivity results and showing initial improvement on topical antibiotic eye drops.
Detailed Description
The primary outcome measures were healing of the corneal perforation, a negative Seidel test and reformation of the anterior chamber.
Secondary outcome measures were improvement of all three of ciliary injection, state of epithelial defect, and corneal infiltration.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Patients with small corneal perforations measuring < 1 mm in diameter. Those with larger perforations (>1mm) were excluded.
- •Patients with conclusive results of keratitis (confirmed via culture and sensitivity scraping) AND showing improved keratitis following antibiotic treatment. Those with no confirmed keratitis through C&S or with inconclusive scraping results were excluded.
- •No age or gender restrictions were applied.
Outcomes
Primary Outcomes
Size of corneal perforation
Time Frame: one week
Size of corneal perforation will be measured in mm using slit lamp examination
Secondary Outcomes
- size of epithelial defect(one week)
Investigators
Nancy Lotfy, MD
Associate Professor of Ophthalmology
Cairo University