Effect of Various Treatment Modalities on Dendritic Vial Ulcer

• Conditions: Corneal Ulcer
• Interventions: Drug: Acyclovir; Drug: Tobramycin; Drug: Sodium Hyaluronate; Drug: Fluorometholone

• Registration Number: NCT05313828
• Lead Sponsor: Sohag University

Brief Summary

Eye infection is a prevalent problem in primary care and remains a crucial healthcare concern. According to the American Academy of Ophthalmology (AAO), herpes simplex virus (HSV) keratitis (HSK) is the leading cause of infectious blindness worldwide . HSK is defined as a corneal inflammatory condition caused by the HSV infection . The global incidence of herpetic keratitis is estimated at 1.5 million per year, resulting in 40,000 new cases of severe visual impairment associated with corneal scarring and opacification . HSV type I (HSV-1) is by far the most predominant causative pathogen of eye infections\]. HSV-1 is also known for causing orolabial herpes, HSV folliculitis, herpes gladiatorum, herpetic whitlow, and eczema herpeticum . HSV can be transferred to the eye by touching an active lesion and then the eye. The National Health and Nutrition Evaluation revealed a seroprevalence of HSV-1 in 53.9% of 14-49 year olds, and 90% of adults 50 years or older , indicating that the majority of the population has been exposed to this virus thus are at risk of developing HSK.

In this study we evaluate the efficacy of different treatment modalities on viral keratitis HSK.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-18
• Study First Submitted: 2022-03-26
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-04
• Last Update Submitted: 2022-04-04
• Study First Posted: 2022-04-06
• Last Update Posted: 2022-04-06
• Primary Completion: 2022-06-28
• Study Completion: 2022-07-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

patients with epithelial viral ulcers

Exclusion Criteria

• patients with stromal keratitis patients with corneal opacity

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group 4	Tobramycin	patients with viral ulcers will receive antiviral medication with antibiotics followed by weak steroid after epithelial healing
group 1'	Tobramycin	patients with viral ulcers will receive antiviral medication with antibiotics
group 2	Acyclovir	patients with viral ulcers will receive antiviral medication, tear substitutes with antibiotics
group 1'	Acyclovir	patients with viral ulcers will receive antiviral medication with antibiotics
group 2	Tobramycin	patients with viral ulcers will receive antiviral medication, tear substitutes with antibiotics
group 3	Acyclovir	patients with viral ulcers will receive antiviral medication, weak steroids(at the same time) with antibiotics
group 2	Sodium Hyaluronate	patients with viral ulcers will receive antiviral medication, tear substitutes with antibiotics
group 3	Tobramycin	patients with viral ulcers will receive antiviral medication, weak steroids(at the same time) with antibiotics
group 3	Fluorometholone	patients with viral ulcers will receive antiviral medication, weak steroids(at the same time) with antibiotics
group 4	Acyclovir	patients with viral ulcers will receive antiviral medication with antibiotics followed by weak steroid after epithelial healing
group 4	Fluorometholone	patients with viral ulcers will receive antiviral medication with antibiotics followed by weak steroid after epithelial healing

Primary Outcome Measures

Name	Time	Method
healing of the epithelium	10 days follow up	the epithelial healing assessed with flourescin stain and measured by slit lamp scale in millimetres and compared with pre treatment epithelial defect

Trial Locations

Locations (1)

Sohag University; 🇪🇬 Sohag, Egypt