Clinical Validation of Computed Tomography derived Myocardial Perfusion Imaging : a Hybrid PET/CT Study (ContRaSt)

Completed

• Conditions: coronary artery disease; myocardial perfusion; 10011082

• Registration Number: NL-OMON51073
• Lead Sponsor: niversitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet
all of the following criteria:
1. Patients admitted for CCS diagnosis and ischemia detection with
intermediate pre-test probability (PTP) between 15% and 85%3.
2. Patients able to give informed consent.
3. 40-80 years old.

Exclusion Criteria

• Renal insufficiency with the glomerular filtration rate less the
30ml/min/kg.
• Known or suspected iodinated contrast allergy.
• Prior stenting or Coronary Artery Bypass Grafting (CABG).
• Atrial fibrillation or other arrhythmia.
• Tachycardia.
• Pacemaker.
• BMI larger than 30 kg/m2 or weight larger than 120 kg
• Not able to hold breath for 20-30 seconds
• Possible pregnancy
•Individuals with high radiation exposure

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the validation of rest phase MPI-CT against the gold<br /><br>standard of rest phase 15O-water PET-CT.<br /><br>The main parameter we are going to measure is myocardial blood flow (MBF).<br /><br>Myocardial perfusion will be calculated quantitatively by a software as MBF in<br /><br>ml/g/min based on CT acquisitions. MBF is calculated on a per voxel basis by<br /><br>dividing the maximal slope of time-attenuation curve (TAC) by the area under<br /><br>the maximum arterial input function (AIF). The arterial input function is<br /><br>sampled from two regions of interest (ROI) placed separately in the descending<br /><br>aorta with every table position (cranial and caudal) and combined into one<br /><br>arterial input function.<br /><br><br /><br>MBF=(Max Slope TAC)/(Maximum AIF)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>