Measuring gastric emptying by use of MRI

Completed

Conditions: normale fysiologie van het Maagdarmstelsel
fysiologie of gastric emptying

Registration Number: NL-OMON41043

Lead Sponsor: Wageningen Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 17

Inclusion Criteria

Male
18-35
BMI: 18.5 - 25.0 kg/m2
Healthy as judged by the participant

Exclusion Criteria

• Failing to meet one or more of the inclusion criteria
• Having difficulties with swallowing/eating
• Weight loss or weight gain of 5 kg or more during the last two months
• Having an endocrine or gastrointestinal disorder which may affect gastric emptying.
• Being allergic/intolerant for products under study (see form F1)
• Working at the Division of Human Nutrition (WUR)
• Current participation in other research from the Division of Human Nutrition (WUR)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is stomach size/content as measured by MRI over a time<br /><br>of 2 hours. The outcome of the study is the difference in these measured<br /><br>parameters between the 4 treatments. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Participants will be asked to rate their feelings of appetite on a<br /><br>questionnaire just before and after they are scanned. This questionnaire will<br /><br>consist of four dimensions of appetite, i.e. hunger, fullness, desire to eat<br /><br>and prospective consumption. Moreover, participants will rate their thirst, and<br /><br>wellbeing i n this questionnaire. In addition, palatability and desire to<br /><br>consume the stimuli will be rated in the scanner. Responses will be reported<br /><br>on 100-mm visual analogue scales.<br /><br><br /><br>Exhaled air is measured for for isotopic enrichment using mass spectrometry, in<br /><br>order to compare this with the MRI data.</p><br>