Predictive Models of Treatment Responses and Survival Outcomes in Patients With Soft Tissue Sarcoma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- Progression-free survival outcomes
研究概览
简要总结
The aim of this study was to developed and validated models to predict therapeutic responses and patients' survivals in patients with soft tissue sarcoma and compared these models with currently available models.
详细描述
We performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict treatment responses and survival outcomes in patients with biopsy-proven soft tissue sarcoma. Secondly, we aimed to compare the predictive accuracy with currently available noninvasive model.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving no treatment before diagnosis
- •With written informed consent
排除标准
- •Clinical data missing
- •Without written informed consent
结局指标
主要结局
Progression-free survival outcomes
时间窗: At least 5-year follow up
The endpoint was defined as the occurrence of progression or recurrence, or the last follow-up. Patients were followed from the day of histological diagnosis until the occurrence of progression or recurrence, or last visit. The outcome was evaluated by an experienced oncologist in each center every 3-6 months. At each visit, a medical history, physical examination, and standard laboratory tests were performed.
Treatment response
时间窗: At least 1-year follow up
The primary outcome was the evaluation of treatment response to individualized therapy in patients with soft tissue sarcoma.
Overall survival outcomes
时间窗: At least 5-year follow up
The endpoint was defined as the occurrence of death or the last follow-up. Patients were followed from the day of histological diagnosis until the occurrence of progression or recurrence or last visit. The outcome was evaluated by an experienced oncologist in each center every 3-6 months. At each visit, a medical history, physical examination, and standard laboratory tests were performed.
次要结局
未报告次要终点
研究者
Yuhan Yang
Associate Professor
West China Hospital