Development of a Predictive Model for Treatment Outcome and Treatment-related Morbidity in a Prospective Cohort Study of Patients With Lymphoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 953
- 试验地点
- 1
- 主要终点
- all cause mortality
研究概览
简要总结
The purpose of this study is to establish a model which can predict the treatment outcome and the risk of treatment-related morbidity in patients with lymphoma.
详细描述
Although the cure rate of lymphoma has been increased due to the development of newer effective drugs, a substantial portion of patients is still suffered from relapse. Furthermore, the treatment-related morbidity is another factor which can make the treatment outcome worse in patients with lymphoma, especially elderly patients. Thus, this study is going to assess following factors which amy probably affect the treatment outcome and the risk of treatment-related morbidity.
- Biologic factors associated with the aggressiveness of lymphoma
- molecular markers in serum, cytogenetic markers
- Factors associated with the risk of treatment-related morbidity
- comorbidity, nutrition status, performance status, quality of life at diagnosis
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were diagnosed as lymphoma
- •Over 15 years old
- •Patients who agreed the enrollment of study
- •Informed consent for sampling
排除标准
- •Patients who do not want to join the study
研究组 & 干预措施
Lymphoma
patients diagnosed as lymphoma
干预措施: Chemotherapy with or without radiotherapy (Drug)
结局指标
主要结局
all cause mortality
时间窗: 5 years
次要结局
- Treatment response(after completion of primary therapy)
- Rate of occurrence of toxicity(2 years from the start of the 1st therapy)
- Treatment-related morbidity(within 60 days from the previous therapy)
研究者
Kim, Seok Jin
Associate Professor
Samsung Medical Center