Efficacy of Stromal Vascular Fraction on Acne Scar Correction

Not Applicable

Not yet recruiting

• Conditions: Acne Scars; Acne Scars - Atrophic
• Interventions: Biological: stromal vascular fraction (SVF); Other: Normal Saline (NS)

• Registration Number: NCT07094958
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study aims to evaluate the efficacy and safety of intradermal injection of autologous stromal vascular fraction (SVF) in the treatment of atrophic acne scars. SVF is a heterogeneous cell population derived from adipose tissue, containing various regenerative and immunomodulatory cells, including mesenchymal stem cells, endothelial progenitor cells, and pericytes.

In this prospective, randomized, split-face clinical trial, participants with atrophic acne scars will receive SVF injections on one side of the face and normal saline (NS) injections on the contralateral side as a control. Clinical efficacy will be assessed through blinded scar counts, digital imaging, and histological evaluations including epidermal and dermal regenerative markers. The study is designed to investigate whether SVF provides superior clinical improvement compared to placebo.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-07
• Study Start: 2025-07-01
• Study First Submitted: 2025-07-29
• Study First Submitted QC: 2025-07-29
• Last Update Submitted: 2025-07-29
• Study First Posted: 2025-07-31
• Last Update Posted: 2025-07-31
• Primary Completion: 2025-12
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Age between 19 and 45 years
• Presence of bilateral atrophic acne scars (boxcar, rolling, or icepick types) on the face
• Willingness to undergo fat harvesting procedure
• Ability to comply with study visits and follow-up
• Written informed consent obtained

Exclusion Criteria

• Active acne lesions on the treatment area
• History of keloid or hypertrophic scarring
• Prior treatment for acne scars (e.g., laser, filler, microneedling) within the past 6 months
• History of systemic immunosuppressive therapy within the past 3 months
• Pregnant or breastfeeding women
• Any systemic disease that may interfere with wound healing or safety assessment (e.g., uncontrolled diabetes, collagen vascular disease)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
SVF-treated side	stromal vascular fraction (SVF)	Intradermal injection of autologous stromal vascular fraction (SVF) on one side of the face.
Saline-treated side	Normal Saline (NS)	Intradermal injection of normal saline (NS) on the contralateral side of the face.

Primary Outcome Measures

Name	Time	Method
Change in total number of atrophic acne scars from baseline to Week 5	Baseline and 5 weeks after treatment
Change in total number of atrophic acne scars from baseline to Week 10	Baseline and 10 weeks after treatment