NCT07014644已完成2 期
A Randomized, Double-blind, Single-center Clinical Study to Evaluate the Efficacy and Safetyof Naltrexone Implant in Antagonizing Opioid Agonist Hydromorphone
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Effective Antagonistic Dose of Naltrexone Implant for Opioid Antagonism
研究概览
简要总结
This study adopted a randomized, double-blind study design to evaluate the antagonistic effect, safety and pharmacokinetics of Naltrexone (opioid receptor antagonist) implantation after Hydromorphone (opioid receptor agonist) challenge.By using the method of multiple Hydromorphone challenge tests and assessing the clinical symptoms and signs related to opioid agonism as well as the pharmacokinetic parameters of Naltrexone and Hydromorphone, this study aimed to investigate the antagonistic effect of different doses of Naltrexone Implants post dosing in different time periods on different doses of Hydromorphone, to understand the ability of Naltrexone to antagonize Hydromorphone and its effective blood concentration, and to explore the effective dose and duration of Naltrexone Implants in antagonizing Hydromorphone. The study also aimed to provide a basis for the clinical use of Naltrexone Implants in the anti-relapse treatment of opioid dependence, and to provide a reference for the design of Phase 3 clinical studies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female subjects aged 18 to 65 years;
- •Those who had abused opioids for more than 1 year, and had used drugs at least once aweek in the abuse history;
- •Opioid-dependent subjects in the convalescent stage who had discontinued using opioids for more than 30 days and had a negative urine test for opioids;
- •Weight: male ≥ 45 kg, female ≥ 40 kg;
- •Physical condition: the subjects were screened within 2 weeks before the study, and had no medical history of heart, liver, kidney, digestive tract, nervous system, mental abnormality or metabolic abnormality; comprehensive physical examinations showed that the subjects had normal or abnormal but not clinically significant electrocardiogram, blood pressure, heart rate, respiratory status and laboratory tests including chest X-ray (results within half a year were valid), blood routine, urine routine, hepatic function, renal function, blood glucose, blood lipid, coagulation function and other biochemical tests at the discretion of the clinician;
- •Subjects without eye disease or optic neuropathy;
- •The subjects and their witnesses must give informed consent to this study before the study, and the subjects voluntarily signed a written informed consent;
- •The subjects could communicate well with the investigator and complete the study in accordance with the study regulations.
排除标准
- •(1) Patients with clinically significant major diseases or major surgical operations within 4 weeks before the study; (2) Those with a history of heart, kidney, digestive tract and other important organs and hematopoietic system diseases; (3) Patients with bleeding tendency and leukopenia; (4) Patients with chronic pain or epilepsy; (5) Patients with serious mental and neurological diseases; (6) Patients with suicidal tendency; (7) Those who had a history of allergy to Hydromorphone or those who were allergic to Naltrexone and its excipients; (8) Those with blood loss or blood donation up to 200 ml within 3 months before the study; (9) Those who had participated in clinical studies of other drugs within 3 months before the study, or were participating in clinical studies of other drugs; (10) Those who had used drugs known to damage a certain organ or were currently using such drugs within 3 months before the study; (11) Those who had used prescription analgesics or psychiatric drugs within 30 days before the study; (12) Those who had used any drug that would inhibit or induce hepatic metabolism of drugs within one week before the study (e.g.: inducers - barbiturates, carbamazepine, phenytoin, glucocorticoids, omeprazole; inhibitors - SSRI antidepressants, cimetidine, diltiazem macrolides, nitroimidazoles, sedative-hypnotics, verapamil, fluoroquinolones, antihistamines); (13) Any other surgical or medical condition that could potentially jeopardize the subject's participation in the study and alter the absorption, distribution, metabolism, and excretion of the drug, including the following:
- •Inflammatory bowel syndrome, peptic ulcer, or gastrointestinal bleeding;
- •History of serious gastrointestinal surgery, such as gastrectomy, gastrostomy, or colectomy;
- •History of liver disease and hepatic function laboratory tests such as: alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase(γ-GT), or total bilirubin (T-Bili) greater than 1.5 × upper limit of normal (ULN) and judged by the clinician as abnormal and clinically significant；4) Clinically significant abnormalities in medical history or laboratory tests for creatinine, blood urea nitrogen, or urine components (e.g., proteinuria), suggesting renal impairment; (14) Those with a history of immunodeficiency, including a positive HIV test; (15) Those who were not suitable to participate in the study at the discretion of the investigator. In addition to the above requirements, female subjects who met the following conditions should also be excluded: (16) Those who took oral contraceptives 30 days before the study; (17) Those who had used within 6 months before the study and might use during the study long-acting estrogen or progestin injections or implants; (18) Women of childbearing age who had experienced unprotected sexual intercourse with their partners within 14 days before the study; (19) Women in pregnancy or lactating;
研究组 & 干预措施
0.9 g
Experimental
干预措施: 0.9g Naltrexone Implant + 0.6g Naltrexone Implant Placebo (Drug)
1.5 g
Experimental
干预措施: 1.5g Naltrexone Implant (Drug)
结局指标
主要结局
Effective Antagonistic Dose of Naltrexone Implant for Opioid Antagonism
时间窗: 150 day
Effective Antagonistic Dose of Naltrexone Implant for Opioid Antagonism
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
A Clinical Study to Evaluate the Efficacy of an Anti-Aging SerumFine LinesWrinklePhotoagingNCT05271136Revision Skincare26
终止
2 期
A Study, Performed in Subjects With Post Traumatic-post Surgical ,Venus Insufficiency and Diabetic Hard to Heal/Chronic Wounds, to Evaluate the Safety and Efficacy of PolyHeal-2 Versus PolyHeal in Once Daily RegimenSurgical Wound DehiscenceNCT01679678MediWound Ltd15
已完成
1 期
Study to Assess the Safety and Tolerability of MBF-118 in Healthy VolunteersCancerNCT05921916Medibiofarma S.L.56
已完成
1 期
Study to Assess the Safety and Tolerability of MBF-015 in Healthy Young VolunteersSafety and PharmacokineticNCT06049147Medibiofarma S.L.72
已完成
1 期
To Assess Pharmacokinetics, Safety and Tolerability of TEV-48125 in Japanese and Caucasian Healthy Subjects After a Single Subcutaneous (SC) Administration of TEV-48125PharmacokineticsNCT02673567Teva Branded Pharmaceutical Products R&D, Inc.64