Clinical Study to Evaluate the Safety and the Efficacy of EscharEx Drug Product (EX-03 Formulation) and Its Placebo Compared to Collagenase, Non-surgical Standard of Care, in Patients With Venous Leg Ulcers
- Conditions
- Venus Leg Ulcers
- Interventions
- Drug: EscharEx (EX-03)Drug: Placebo (Gel vehicle)
- First Posted Date
- 2024-11-15
- Last Posted Date
- 2024-11-15
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 45
- Registration Number
- NCT06690177
- Locations
- 🇺🇸
ILD Research Center, Carlsbad, California, United States
🇵🇱Wojskowy Instytut Medyczny, Warsaw, Poland
A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)
- Conditions
- Venous Leg Ulcer (VLU)
- Interventions
- Drug: EscharEx (EX-03)Drug: Placebo (Gel vehicle)
- First Posted Date
- 2024-08-23
- Last Posted Date
- 2025-04-24
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 216
- Registration Number
- NCT06568627
- Locations
- 🇺🇸
Limb Preservation Platform, Inc, Fresno, California, United States
🇺🇸Center for Clinical Research INC, San Francisco, California, United States
🇺🇸Northwell Health Comprehensive Wound Healing Center, Lake Success, New York, United States
A Study to Evaluate the Safety and Efficacy of EscharEx (EX-02) in the Treatment of Basal Cell Carcinoma
- Conditions
- Nodular Basal Cell CarcinomaSuperficial Basal Cell Carcinoma
- Interventions
- Drug: EscharEx 5% (EX-02 formulation)
- First Posted Date
- 2021-12-15
- Last Posted Date
- 2021-12-15
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 32
- Registration Number
- NCT05157763
- Locations
- 🇺🇸
Center for Clinical and Cosmetic Research, Aventura, Florida, United States
🇺🇸Moore Clinical Research, Inc., Brandon, Florida, United States
🇺🇸Center for Clinical Studies, LTD. LLP, Webster, Texas, United States
A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers
- Conditions
- Venous Leg UlcerDiabetic Foot Ulcer
- Interventions
- Drug: EscharEx (EX-02 formulation)
- First Posted Date
- 2021-03-26
- Last Posted Date
- 2022-07-26
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 12
- Registration Number
- NCT04817228
- Locations
- 🇺🇸
Barry University foot and ankle institute, Tamarac, Florida, United States
🇺🇸Clinical Research Medical Center, LLC, Las Vegas, Nevada, United States
🇺🇸University of North Carolina, Chapel Hill, North Carolina, United States
Use of NexoBrid for Treatment of Acute Deep Partial and Full Thickness Burn Injuries
- Conditions
- Thermal Burn
- First Posted Date
- 2019-08-01
- Last Posted Date
- 2024-08-30
- Lead Sponsor
- MediWound Ltd
- Registration Number
- NCT04040660
- Locations
- 🇺🇸
University of South Alabama, Mobile, Alabama, United States
🇺🇸Valleywise Health Medical Center, Phoenix, Arizona, United States
🇺🇸University of California, Irvine, Orange, California, United States
A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers
- Conditions
- Venous Leg Ulcer
- Interventions
- Drug: EscharEx (5% EX-02 formulation)Drug: Gel VehicleDrug: Non-surgical standard of care (NSSOC)
- First Posted Date
- 2018-07-17
- Last Posted Date
- 2022-11-14
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 120
- Registration Number
- NCT03588130
- Locations
- 🇺🇸
ILD Research Center, Carlsbad, California, United States
🇺🇸Limb Preservation Platform, Inc., Fresno, California, United States
🇺🇸Felix Sigal. D.P.M, PC, Los Angeles, California, United States
A Study to Evaluate the Efficacy and Safety of NexoBrid in Children With Thermal Burns Compared the Standard of Care
- First Posted Date
- 2014-10-30
- Last Posted Date
- 2022-07-27
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 145
- Registration Number
- NCT02278718
- Locations
- 🇺🇸
Maricopa Special Health Care District, Phoenix, Arizona, United States
🇺🇸University Of Florida, Gainesville, Florida, United States
🇺🇸University of Miami, Miami, Florida, United States
A Study to Evaluate the Efficacy and Safety of NexoBrid in Subjects With Thermal Burns
- Conditions
- Thermal Burns
- Interventions
- First Posted Date
- 2014-05-28
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 175
- Registration Number
- NCT02148705
- Locations
- 🇺🇸
University of South Alabama Department of Surgery, Mobile, Alabama, United States
🇺🇸Maricopa Medical Center, Phoenix, Arizona, United States
🇺🇸University of Colorado at Denver, Teaching, Aurora, Colorado, United States
Efficacy and Safety Study of EscharEx to Treat (Debride) Hard to Heal Wounds
- Conditions
- Hard to Heal WoundsVenous Leg UlcersDiabetic Lower Extremity UlcersTraumatic/ Post Operative Wounds
- Interventions
- Drug: Gel Vehicle
- First Posted Date
- 2013-12-25
- Last Posted Date
- 2018-08-31
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 111
- Registration Number
- NCT02020746
- Locations
- 🇮🇱
Emek, Afula, Israel
🇮🇱Rambam MC - Plastic surgery ward, Haifa, Israel
🇮🇱Meir MC, Kfar Saba, Israel
Functionality Assessments in Patients (Adults and Children) Following Treatment With Debrase Compared to Standard of Care
- Conditions
- Burns, Upper ExtremityBurns, Lower Extremity
- First Posted Date
- 2013-02-28
- Last Posted Date
- 2013-02-28
- Lead Sponsor
- MediWound Ltd
- Target Recruit Count
- 53
- Registration Number
- NCT01800981
- Locations
- 🇸🇰
Clinic of Burns and reconstructive surgery hospital, Kosice, Slovakia