EUCTR2013-002807-32-DK
Active, not recruiting
Not Applicable
Antibiotic treatment for patients with infectious endocarditis: continuous infusion, guided by therapeutic drug monitoring, versus intermittent infusions (the CONTENT study). - CONTENT
Aarhus University Hospital, Department of Cardiology0 sites40 target enrollmentSeptember 3, 2013
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Aarhus University Hospital, Department of Cardiology
- Enrollment
- 40
- Status
- Active, not recruiting
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Verified infectious endocarditis, with bacteria in the blood, susceptible for either Benzylpenicillin or Diclocil.
- •2\. Less than 96 hours since the onset of intra venous antibiotic treatment.
- •3\. Use of contraception (for fertile women)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 10
- •F.1\.3 Elderly (\>\=65 years) yes
- •F.1\.3\.1 Number of subjects for this age range 30
Exclusion Criteria
- •1\. Negative blood cultures.
- •2\. More than 96 hours since the onset of intra venous antibiotic treatment.
- •3\. Planned valve surgery.
- •4\. Planned extraction of a pace maker.
- •5\. Allergy to Benzylpenicillin or Diclocil.
- •6\. Unability to understand information about the study and to give informed consent.
- •7\. Age under 18\.
- •8\. Preagnancy.
- •9\. Breastfeeding.
Outcomes
Primary Outcomes
Not specified
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