CTIS2024-514900-16-00进行中（未招募）1 期
Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study - 2019-003282-17
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 380
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •Age >18 years, Blood culture positive for Gram-negative bacteria, Evidence of urinary tract source of infection (positive urine culture or at least one clinical symptom compatible with urinary tract infection), Antibiotic treatment with antimicrobial activity to Gram-negative bacteria administrated within 12 hours of first blood culture, Temperature <37.8°C at randomization, Clinically stabile at randomization (systolic blood pressure > 90 mm Hg, heart rate <100 beats/min., respiratory rate <24/minute, peripheral oxygen saturation > 90 %), Oral and written informed consent
排除标准
- •Antibiotic treatment (>2 day) with antimicrobial activity to Gram-negative bacteria within 14 days of inclusion, Gram-negative bacteremia within 30 days of blood culture, Immunosuppression (Untreated HIV-infection, Neutropenia (absolute neutrophil count < 1.0 x 109/l), Untreated terminal cancer, Receiving immunosuppressive agents (ATC-code L04A), Corticosteroid treatment (=20 mg/day prednisone or the equivalent for >14 days) within the last 30 days, Chemotherapy within the last 30 days, Immunosuppressed after solid organ transplantation, Asplenia), Polymicrobial growth in blood culture, Bacteremia with non-fermenting Gram-negative bacteria (Acinetobacter spp, Burkholderia spp, Pseudomonas spp), Brucella spp, or Fusobacterium spp, Failure to remove source of infection within 72 hours of first blood culture (e.g. change of catheter á demeure), Pregnancy or breastfeeding
研究者
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