NL-OMON47609已完成4 期
Short versus extended antibiotic treatment with a carbapenem for high-risk febrile neutropenia in hematology patients with Fever of Unknown Origin: a randomized multicenter open-label non-inferiority trial. - SHORT-trial
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- VUmc
- 入组人数
- 276
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1.Patients with malignant hematological diseases being treated with cytotoxic chemotherapy or stem cell transplantation;;2.High-risk neutropenia;;3.Fever;;4.Age 18 years or older;;5.Written informed consent.
排除标准
- •1.Contraindications to use of imipenem-cilastatin or meropenem such as allergy, previous severe side-effects or previous microbiological cultures with carbapenem-resistant microorganism(s).;2.Corticosteroid use *10 mg per day prednisolone or equivalent for more than 3 consecutive day during the previous 7 days.;3.Clinically or microbiologically documented infection. ;4.Symptoms of septic shock (systolic blood pressure <90 mm Hg unresponsive to fluid resuscitation and/or oliguria (urine production <500mL/day)).;5.Previous enrollment in this study during the same episode of neutropenia. ;6.Any critical illness for which Intensive Care Unit treatment is required.;7.Legal incompetency
研究者
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