Effect of lignocaine on biological markers in bowel surgery
Phase 4
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/03/032273
- Lead Sponsor
- Government medical college and hospital Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1.ASA (American Society of Anesthesiologists) grade I-II patients
2.Patients scheduled to undergo restoration of bowel continuity
Exclusion Criteria
1.Cardiac conduction abnormalities and congestive heart failure
2.Renal or hepatic impairment
3.Neurological disorders
4.Pregnant and lactating women
5.Patients not able to understand VAS
6.History of substance abuse
7.Contraindications to study drugs: lignocaine, paracetamol ,tramadol and diclofenac
8.Chronic pain conditions, neurodegenerative or autoimmune disorders.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum lactate dehydrogenase (LDH) and lactate levelsTimepoint: Baseline before surgery, before extubation, after 6h ,24h
- Secondary Outcome Measures
Name Time Method 1.Visual analogue scale at rest and on movement <br/ ><br>2.Time to rescue analgesia and total rescue analgesia <br/ ><br>3.Arterial blood gas(ABG) analysis <br/ ><br>4.Haemodynamics <br/ ><br>Timepoint: 1. VAS score: baseline, post extubation, 1h in postoperative care unit (PACU), at 6h, 12 h and 24 h. <br/ ><br>2. Time to first rescue and total analgesia: in PACU and in postoperative period upto <br/ ><br>24 h. <br/ ><br>3. Baseline before surgery, before extubation, after 6h ,24h <br/ ><br>4.Haemodynamics (PR, BP,RR): baseline, at time of induction, after intubation, every 5 minutes during surgery, at time of extubation, every 5 minutes for 15 min, every 15 minutes upto 1 h in PACU, then in ward at 6 h, 12 h and 24 h. <br/ ><br> <br/ ><br>