Individualized care with antipsychotics in patients suffering from schizophrenia spectrum disorders-How to conciliate plasma concentrations, clinical response and genetic factors ?

CLouvain0 个研究点目标入组 100 人开始时间: 2021年10月12日最近更新: 2024年3月12日

适应症

试验速览

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•Inclusion criteria are : (1) diagnosis of schizophrenia-spectrum disorders7 (DSM-V 295.xx,
•298.9 and 297.1 ; or ICD-10 F20.xx, F25.xx, F29 and F22; or ICD-11 6A20, 6A21, 6A2Z and
•6A24), (2) hospitalized in a psychiatric unit of each center for an acute episode of psychosis, (3) aged between 18 and 65 years old at admission; and (4) taking a monotherapy8 of
•aripiprazole, olanzapine or risperidone at admission or any time during their hospital stay for
•their psychotic symptoms until steady state of their antipsychotic is reached.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 100
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion criteria are: (1) comorbid disorder of intellectual development (i.e. intellectual
•disability also commonly called mental retardation, DSM-V criteria 317.xx and 318.xx), (2)
•comorbid serious uncontrolled illness or dementia9; (3) comorbid substance use disorder (DSMV
•305.20, 304.30, 305.90, 304.60, 305.30, 304.50, 305.50, 304.00, 305.40, 304.10, 305.70,
•305.60, 304.40, 304.20) in case of consumption during the hospital stay10 (4) comorbid alcohol
•use disorder (DSM-V 305.00 and 303.90); (5) women with a current pregnancy11 ; (6)
•hospitalization for a social purpose (e.g. nursing home time out) or planned hospitalization
•without exacerbation ; (7) patients not speaking French, English or Dutch to a standard
•necessary to receive the assessment scales; (8) patients with an hepatic fibrosis Child Pugh C
•and severe renal failure (i.e. Clcr <30 mL/min) identified through chart review.

发起方

CLouvain