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Clinical Trials/NCT04256239
NCT04256239
Unknown
Not Applicable

Dignity Therapy for Terminally Ill Patients: A Randomized Controlled Trial

European University of Rome1 site in 1 country55 target enrollmentFebruary 28, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Emotional Stress
Sponsor
European University of Rome
Enrollment
55
Locations
1
Primary Endpoint
Change from Pre-test to Post-test and Follow-up in Spiritual Well-Being, which will be reported in the outcome measure results data table as means and standard deviations.
Last Updated
6 years ago

Overview

Brief Summary

We conducted a randomized, controlled trial of dignity therapy for terminally ill patients with the aim of reducing dignity-related distress and demoralization and improving spiritual well-being.

Detailed Description

Sample size assessment: A recent meta-analysis showed that dignity interventions reach on average effect sizes of -1.01 on emotional distress (Ho and Shin, 2014). Power analysis showed that with an alpha of 0.05 and a power of 0.80, we needed a sample of 26 participants to detect effect sizes of 1.01 and higher. Plan for missing data: Occasional missing values were imputed by calculating, for each participant, the average score for each subscale and then replaced. Statistical analysis plan: We conducted a 2 (group) X 3 (time \[pre-treatment vs. post-treatment vs follow-up\]) repeated measures multivariate analysis of variance (MANOVA) for a set of variables

Registry
clinicaltrials.gov
Start Date
February 28, 2018
End Date
December 31, 2022
Last Updated
6 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
European University of Rome
Responsible Party
Principal Investigator
Principal Investigator

Luca Iani

Associate Professor

European University of Rome

Eligibility Criteria

Inclusion Criteria

  • age over 18,
  • diagnosis of life-threatening disease with a prognosis of six months or less,
  • no evidence of dementia (as determined by retrospective assessments),
  • the ability to read and speak Italian and provide written informed consent,
  • the availability for six to seven research encounters over the period of three weeks

Exclusion Criteria

  • psychotic illness,
  • dementia and severe neurological impairment

Outcomes

Primary Outcomes

Change from Pre-test to Post-test and Follow-up in Spiritual Well-Being, which will be reported in the outcome measure results data table as means and standard deviations.

Time Frame: Pre-test (before the intervention), Post-test (7-10 days after the baseline assessment), Follow-up (15-20 days after the baseline assessment).

Spiritual well-being will be measured with the FACIT-Sp (minimum value=0; maximum value=48, with higher scores indicating a better outcome), a questionnaire assessing faith, peace and meaning

Secondary Outcomes

  • Change from Pre-test to Post-test and Follow-up in Demoralization, which will be reported in the outcome measure results data table as means and standard deviations.(Pre-test (before the intervention), Post-test (7-10 days after the baseline assessment), Follow-up (15-20 days after the baseline assessment))
  • Change from Pre-test to Post-test and Follow-up in Dignity-related Distress, which will be reported in the outcome measure results data table as means and standard deviations.(Pre-test (before the intervention), Post-test (7-10 days after the baseline assessment), Follow-up (15-20 days after the baseline assessment))

Study Sites (1)

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