The Effect of the Combined Use of Naloxone and Tramacet on Postoperative Analgesia in the Elderly

Phase 4

Completed

• Conditions: Arthroplasty
• Interventions: Drug: tramacet

• Registration Number: NCT00665262
• Lead Sponsor: Lawson Health Research Institute

Brief Summary

Ten patients 70 years and older having elective total hip/knee replacement surgery will be recruited to receive a continuous IV infusion of naloxone and oral tramacet for analgesia. Postoperative analgesia, satisfaction, side effects, need for rescure analgesia, and length of stay.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-12-17
• Study First Submitted: 2008-04-18
• Study First Submitted QC: 2008-04-18
• Study First Posted: 2008-04-23
• Primary Completion: 2010-11-30
• Study Completion: 2011-08-12
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-25
• Last Update Posted: 2017-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• aged 70 years or older able to give consent able to communicate in English having elective hip/knee arthroplasty ASA physical status 1-3

Exclusion Criteria

• allergies to any of the following: naloxone, tramacet, NSAIDs, sulpha, or local anesthesic contraindication to spinal anesthesia contraindication to use of tramacet or celebrex ASA physical status4 chronic opiod use chronic pain syndrome

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	tramacet	comibined use of tramacet and naloxone infusion perioperatively

Primary Outcome Measures

Name	Time	Method
opoid use post knee/hip arthroplasty	post-op period

Secondary Outcome Measures

Name	Time	Method
incidence of visual analogue scale scores greater than 4	post-op period

Trial Locations

Locations (1)

St. Joseph's Health Care; 🇨🇦 London, Ontario, Canada