Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient
Early Phase 1
Recruiting
- Conditions
- Blood Loss, Surgical
- Interventions
- Other: normal saline
- Registration Number
- NCT05427513
- Lead Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
- Brief Summary
investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
- Limb sarcoma of upper and lower limb
- Limb salvage
Exclusion Criteria
- liver insufficiency
- renal insufficiency
- allergic to drug
- history of thromboembolic condition
- pregnancy
- metastatic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo normal saline will injection 10 ml of normal saline to ensure binding tranexamic acid(TXA) Tranexamic acid injection will inject tranexamic acid according to body weight
- Primary Outcome Measures
Name Time Method blood loss 72 hour post operatively measure by hemoglobin direct method
no of blood transfused 72 hour measured by number of transfusion
- Secondary Outcome Measures
Name Time Method duration of hospital stay total hospital stay post operatively for 02 month Total days of hospital admission 2 months after surgery
volume of drain out put measure till drain out in 72 hour to measure blood collected in drain bottle
thromboembolic events observed for 6 week determine on out patient visits look for limb swelling for deep vein thrombosis and chest symptoms for any embolic event confirmed by CT chest
Trial Locations
- Locations (1)
Shaukat Khanum Memorial Cancer Hospital & Research Center
🇵🇰Lahore, Punjab, Pakistan