Comparison of Bolus Intravenous Lidocaine Administration With Continuous Intravenous Lidocaine Against Post-Extubation Cough Incidence in Post-Thyroidectomy Patients
Overview
- Phase
- Phase 2
- Intervention
- Lidocaine IV
- Conditions
- Cough
- Sponsor
- Universitas Padjadjaran
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Post-Extubation Cough Grade
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this randomized controlled trial is to compare the effect of lidocaine bolus intravenous administration to lidocaine continuous intravenous administration in post thyroidectomy patients to observe the effect against post-extubation cough. The main questions it aims to answer are:
- Cough incidence on both groups
- Which method is preferable to reduce post-extubation cough incidence
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA class 1 and 2
- •Thyroidectomy patients in Hasan Sadikin Bandung Hospital
Exclusion Criteria
- •Subjects' refusal
- •Had history of drug allergy, specifically lidaocaine
- •Had history of asthma or other lung diseases
- •Active smoker
- •History of arrhythmia
- •Bradycardia subjects (\<60 beats per minute)
- •Pregnant people
- •Perioperative upper respiratory tract infusion
- •Routinely consume ACE inhibitor / bronchodilators / steroid
- •Renal dysfunction
Arms & Interventions
Continuous Lidocaine Intravenous Infusion
Patients were given a loading dose of 1.5 mg/kgBW intravenous lidocaine for 10 minutes before induction of anesthesia using a syringe pump, followed by continuous intravenous administration of 1.5 mg/kgBW/hour lidocaine until 30 minutes before the end of the surgery (when the skin is being sutured by the surgeon) using a syringe pump. Continuous administration of lidocaine was prepared by the research team as 10 cc of 20 mg/cc lidocaine in a 10 cc syringe and 10 cc of 0.9% NaCl in a 10 cc syringe.
Intervention: Lidocaine IV
Bolus Lidocaine Intravenous
Patients were given a loading dose of 1.5 mg/kgBW intravenous lidocaine for 10 minutes before induction of anesthesia using a syringe pump, followed by intravenous infusion of saline with the same volume until 30 minutes before the end of the surgery (when the skin is being sutured by the surgeon) using syringe pump.
Intervention: Lidocaine IV
Outcomes
Primary Outcomes
Post-Extubation Cough Grade
Time Frame: 24 hours post operative
Cough graded according to the following criteria: Grade 0: no cough; Grade 1: mild, only 1 cough; Grade 2: moderate, \>1 cough lasting \<5 seconds; Grade 3: coughing heavily and continuously for \>5 seconds)
Secondary Outcomes
- Number of participant experiencing tachycardia(24 hours perioperative)
- Number of participant experiencing hypertension(24 hours perioperative)
- Number of participant experiencing hypotension(24 hours perioperative)
- Number of participant experiencing bradycardia(24 hours perioperative)