A Randomized Clinical Trial Estimating the Efficacy of Bolus Administration of Intravenous Lidocaine at the Time of Abdominal Hysterectomy to Decrease Postoperative Pain
Overview
- Phase
- Not Applicable
- Intervention
- lidocaine
- Conditions
- Abdominal Hysterectomy
- Sponsor
- Aswan University Hospital
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Visual analog score during movement
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The objective of the study to evaluate whether a bolus administration of intravenous lidocaine decreases postoperative pain and represents an opioid-minimizing strategy after abdominal hysterectomy compared with placebo.
Detailed Description
Total abdominal hysterectomy (TAH) is the most common gynecological operation worldwide. Some studies noticed about abused of opioids in postoperative care, led to a more adverse effect of opioids, slow recovery, prolong the length of hospitalized stay and consequently increase the unnecessary cost of treatment. Guidelines have considered using preoperative analgesics for reducing post-operative opioids consumption, including lidocaine infusion. With its anti-inflammatory, anti-hyperalgesia and analgesic properties, intravenous perioperative lidocaine infusion (IVLI) has been used for optimal postoperative care in different surgeries and in various procedures involving hysterectomy. Therefore, the aim of this study is to assess the efficacy of bolus administration of intravenous lidocaine at the time of abdominal hysterectomy to decrease postoperative pain and reducing morphine requirements, after TAH.
Investigators
hany farouk
Principal Investigator
Aswan University Hospital
Eligibility Criteria
Inclusion Criteria
- •Women ranging age between 35-60 years a who undergoing elective total abdominal hysterectomy
Exclusion Criteria
- •Participants had known sensitivity to lidocaine
- •Participants had difficulty in intubation
- •Participants were on chronic pain medication or already on long-term opioids
- •Participants smokers
- •Participants with disabilities who were unable to communicate pain levels
- •refuse to consent
Arms & Interventions
lidocaine
A bolus intravenous dose of 1.5 mg/kg lidocaine 2% over 15 s just before the induction of general anesthesia.
Intervention: lidocaine
Placebo
A bolus intravenous dose of a saline placebo over 15 s just before the induction of general anesthesia.
Intervention: Placebo
Outcomes
Primary Outcomes
Visual analog score during movement
Time Frame: 30 minutes postoperative
movement-evoked pain measurements ranging from 0 to 10, where 0 no pain and 10 maximum pain
Secondary Outcomes
- Visual analog score during rest(24 hours post operative)
- number of patients need Fentanyl consumption(24 hours post operative)
- number of days patients stay in hospital(4 weeks)