Occupational Respiratory Allergies and Gene-environment Interactions
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 12
- 主要终点
- Classification of suspected work-related asthma in occupational asthma, work aggravated asthma, non-work-related asthma
研究概览
简要总结
The purpose is to compare clinical, functional, professional and socio-economical characteristics of patients with occupational asthma and work aggravated asthma.
Secondary purposes are:
- to evaluate diagnostic value of new non-invasive techniques such as exhaled nitric oxide and cytology of induced expectoration;
- to estimate medical-social becoming of diagnosed work-related asthma after one year;
- to establish a biobank of blood samples of individuals with work related asthma for measurement of cytokines and search for genetic polymorphisms associated with asthma.
详细描述
Participants with work related asthma or suspected work related asthma will obtain a precise diagnosis concerning severity and control of respiratory disorder and also the possible effect of professional environment on the disorder. Their medical care and medico-legal care, in case of recognition of occupational disease, could be ameliorated.
In general, this study will allow the harmonization of diagnostic care and medical, medico-professional and medico-legal management of cases of work related asthma in specialized hospitals.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient consulting for suspected work-related asthma in one of hospitals participating to the study
排除标准
- •Patient refusing to participate
- •Pregnant or breastfeeding women
- •Individual in life-threatening emergency
- •Hospitalized patient
- •Patient in a health or social institution
- •Person deprived of liberty
- •Person with total occupational disability
- •Retired person
- •Person diagnosed as non-asthmatic
- •Asthmatic person already enrolled in a clinical trial of bio-therapy to treat asthma
结局指标
主要结局
Classification of suspected work-related asthma in occupational asthma, work aggravated asthma, non-work-related asthma
时间窗: Inclusion
Interpretation of diagnostic algorithm of study
次要结局
- Costs of different types of asthma(Inclusion and after 1 year)
- Cytology of induced expectoration(Inclusion)
- Nitric oxide level(Inclusion)
- Nonspecific bronchial hyperreactivity evaluated with metacholine bronchial challenge test and/or isocapnic hyperventilation test(Inclusion)
- Control of asthma symptoms evaluated with Asthma Control test and peak exploratory flow(Inclusion)
- Severity of symptoms(Inclusion)