Evaluation of the Relationship Between the Parameters of Pulmonary Function (PF) and the Concentration of Fractional Exhaled Nitric Oxide (FeNO) and Clinical Characteristics in Children Being Diagnosed Due to Suspicion of Allergic Diseases
试验速览
- 阶段
- 不适用
- 入组人数
- 5,500
- 试验地点
- 1
- 主要终点
- Allergic disease diagnosis
研究概览
简要总结
The aim of this study is to assess the influence of kind of allergic disease, allergic profile, allergen exposure, treatment method on lung function parameters, fractional exhaled nitric oxide level in children suspected and being diagnosed due to allergic diseases.
详细描述
The aim of this study is to assess the influence of kind of allergic disease, allergic profile, allergen exposure, treatment method on lung function parameters, fractional exhaled nitric oxide (FeNO) level in children suspected and being diagnosed due to allergic diseases.
Study will be retrospective, conducted in all children diagnosed in the years of 2005-20012 in Laboratory of lung function tests of Department of Pediatrics and Allergy, Medical University of Lodz, N. Copernicus Hospital, Lodz, Poland. The investigators will analyse 5500 male an female children 5-18 year old suspected and being diagnosed due to allergic diseases. In these children nearly 3000 FeNO measurements, 65000 spirometry measurements, 22000 whole-body plethysmography measurements and 48000 occlusion resistance measurements were performed between the years of 2005-2012.
The investigators will retrospectively evaluate following data from medical documentation of patients:
- FeNO levels.
- Allergic disease diagnosis.
- Immunoglobulin E (IgE) specific levels.
- Treatment (drugs and dosages).
- Lung function parameters (spirometry, whole-body plethysmography, occlusion resistance, bronchial reversibility test).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 5 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children with allergic diseases, healthy children.
排除标准
- •Other serious diseases.
结局指标
主要结局
Allergic disease diagnosis
时间窗: 7 years
Allergic disease diagnosis. The diagnosis and the severity of asthma, allergic rhinitis and atopic dermatitis and other allergic diseases universally established by the doctors (allergologists) according to standard definitions of diseases in the latest guidelines
次要结局
- Lung function (LF)(7 years)
研究者
Iwona Stelmach
MDPhDProf
Medical University of Lodz