NCT00409903已完成4 期
The Effect of Eprosartan on Vasoactive Hormones and Renal Tubular Function in Healthy Humans.
Regional Hospital Holstebro2 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2006年11月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Heart rate
研究概览
简要总结
We, the investigators at Holstebro Hospital, want to test the hypothesis that eprosartan reduces the activity of the sympathetic nervous system in healthy individuals - during baseline conditions and after activation of the sympathetic nervous system.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Both genders.
- •Age 18 - 65 years.
- •Body mass index less or equal to 30 kg/m
- •Women must use oral hormonal anticonception, use intrauterine anticonceptive device, be sterilized/hysterectomized or be postmenopausal.
排除标准
- •History or clinical signs of heart, lung, kidney, or endocrine organ disease.
- •Abnormal biochemical screening of the blood regarding: B-hemoglobin, P-sodium, P-potassium, P-creatinine, P-albumin, P-bilirubin, P-alanine aminotransferase, P-alkaline phosphatase, P-cholesterol, and B-glucose.
- •Abnormal screening of the urine regarding: albumin and glucose
- •Malignant disease.
- •Known arterial hypertension or measured 24 hour blood pressure above 135 mmHg systolic or 85 mmHg diastolic.
- •Alcohol abuse.
- •Drug use or abuse.
- •Known intolerance or allergy to eprosartan or sodium nitroprusside.
- •Blood donation within 1 month of the start of the study.
结局指标
主要结局
Heart rate
Fractional sodium excretion
Plasma levels of noradrenaline
次要结局
未报告次要终点
研究者
研究点 (2)
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