NCT00438945已完成4 期
The Effect of Eprosartan in Patients With Essential Hypertension on Renal Tubular Function and Vasoactive Hormones During Baseline Conditions and After Activation of the Sympathetic Nervous System.
Regional Hospital Holstebro2 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2007年1月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Fractional sodium excretion
研究概览
简要总结
We, the investigators at Holstebro Hospital, want to test the hypothesis that eprosartan reduces the activity of the sympathetic nervous system in patients with essential hypertension - during baseline conditions and after activation of the sympathetic nervous system.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 - 65 years.
- •Body mass index less or equal to 30 kg/m
- •Women must use oral hormonal anticonceptive drugs, use intrauterine anticonceptive device, be sterilized / hysterectomized or be postmenopausal.
- •Arterial hypertension, defined by 24 hour ambulatory blood pressure above 125 mmHg systolic or above 80 mmHg diastolic.
排除标准
- •History of myocardial infarction.
- •History of stroke.
- •Heart failure.
- •Endocrine organ disease.
- •Lung disease.
- •Clinically significant abnormal biochemical screening of the blood regarding: B-hemoglobin, P-sodium, P-potassium, P-creatinine (under 200 µmol/L will be accepted), P-albumin, p-bilirubin, p-alaninaminotransferase, P-alkaline phosphatase, p-cholesterol and B-glucose.
- •Clinically significant abnormal screening of the urine regarding: albumin and glucose (protein excretion below 0.5 g/L will be accepted).
- •Renovascular hypertension.
- •Malignant disease.
- •Alcohol abuse.
- •Usage of medical drugs besides antihypertensives or statins.
- •Drug abuse.
- •Pregnancy or breast feeding.
- •Known intolerance or allergic to eprosartan or sodium nitroprusside.
- •Blood donation within 1 month of the start of the study.
结局指标
主要结局
Fractional sodium excretion
Plasma levels of noradrenaline
Heart rate
次要结局
- Fractional lithium excretion
- Glomerular filtration rate
- plasma levels of renin, angiotensin II, aldosterone, vasopressin, atrial natriuretic peptide and brain natriuretic peptide
- free water clearance
- urinary excretion of aquaporin 2
研究者
研究点 (2)
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