Evaluation of efficacy of advanced platelet rich fibrin in healing of mandibular fractures- A prospective clinical study
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- healing will be faster for mandibular fractures where we have applied Advanced-platelet rich fibrin
研究概览
简要总结
•A-PRF is a second generation PRF that has been reported to aid in faster wound healing and bone healing due to the enhanced presence of platelets and neutrophilic granulocytes. These cells influence the differentiation of host macrophages after its implantation at the site, which in turn aid with bone and soft tissue regeneration. The release of growth factors like TGF-b1, PDGF, EGF, and IGF have been reported to be greater thereby accelerating the process of bone healing. A-PRF concentrates have shown to cause higher proliferation and migration of hematopoietic growth factors too thereby producing better angiogenesis at the site.
•In this study, the effect of A-PRF on mandibular fracture healing will be evaluated post reduction and fixation of fracture segments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients requiring open reduction with internal fixation of bilateral mandibular fracture under general anesthesia.
- •Patients who are willing and be able to provide informed consent and be available for multiple follow up visits.
- •Patients with the age group ranging from 18-60 years.
排除标准
- •Patients with any preexisting pathology.
- •Patients with uncontrolled systemic illness.
- •Interfragmentary distance between fractures more than 1 mm.
结局指标
主要结局
healing will be faster for mandibular fractures where we have applied Advanced-platelet rich fibrin
时间窗: post-operatively day 1 and 3 months
次要结局
- advanced platelet rich fibrin will be reduce swelling on applied site(post-operatively day-1 & day-7)
研究者
Dr Yash Vyas
Sri Siddhartha Dental College