Glycemic responses to allulose and aspartame in adults living with obesity
Phase 1
Completed
- Conditions
- obesity
- Registration Number
- TCTR20220530003
- Lead Sponsor
- Rajburi Sugar Co., Ltd.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 19
Inclusion Criteria
The inclusion criteria included age between 18-60 years and body mass index (BMI) between 28-35 kg/m2.
Exclusion Criteria
Exclusion criteria included weight changes of 5 kg or more within 6 weeks of enrollment, known allergies to food or substances utilized in the study, antibiotic, NSAID, or steroid use within 6 weeks before registration, bariatric surgery, active gastrointestinal disorders such as inflammatory bowel disease and short bowel syndrome, severe hypertension (defined as systolic blood pressure above 180 mmHg and/or diastolic blood pressure above 110 mmHg), severe hypertriglyceridemia (triglyceride levels above 500 mg/dL), diabetes mellitus, pregnancy, lactation, and history of phenylketonuria.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postprandial glucose 0, 15, 30, 45, 60, 90, and 120 minutes iAUC & peak
- Secondary Outcome Measures
Name Time Method insulin, C-peptide, GLP-1, glucagon, and leptin 0, 15, 30, 45, 60, 90, and 120 minutes iAUC & peak,gut microbiome baseline 16S rRNA sequencing