Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 93
- 试验地点
- 4
- 主要终点
- Number of patients with renal recovery
研究概览
简要总结
Acute kidney injury (AKI) is a common disorder and associated with high morbidity and mortality. However, distinguishing transient AKI from persistent AKI may help in individualizing treatment and limit short and long term consequences of AKI. Previous studies suggested usual urinary indices to perform poorly for separating transient from persistent AKI in an unselected population of critically ill patients. The recent KDIGO (Kidney Disease Improving Global Outcomes) guidelines underlined the need for additional strategies in estimating renal short term prognosis.
Recently, a Furosemide stress test (FST) was validated in a cohort of unselected critically ill patients. This stress test performance was found to be good in predicting capacity to identify those patients that will progress to advanced stage AKI. Additionally, FST performance was higher than those of usual renal biomarker. The limited sample size of this preliminary study however precluded adjustment for usual confounders including oliguria.
The primary objective of this study is to assess diagnostic performance of FST in differentiating transient and persistent AKI. Secondary objectives are to assess diagnostic performance of FST in predicting need for renal replacement therapy, and to confirm FST results after adjustment for confounders.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (age > 18 y.o)
- •AKI stage 1 or more according to KDIGO
- •Oliguria as defined by an oliguria lower than 0.5 mL/Kg
- •Affiliation to the National Medical Insurance
排除标准
- •Pregnancy
- •Chronic kidney disease stage 4 or more
- •Need for fluid bolus (>1000 mL crystalloids or equivalent) or need for vasopressors increases or introduction in the 2 hours preceding inclusion
- •Evidence of obstructive renal failure
研究组 & 干预措施
Furosemide stress test
干预措施: Furosemide (Drug)
结局指标
主要结局
Number of patients with renal recovery
时间窗: day 3
次要结局
- natriuresis(mmol/L)(day 0 to day 3)
- U/P creatinine ratio (mg.dl-1/ mg.dl-1)(day 0 to day 3)
- fractional excretion of sodium(%)(day 0 to day 3)
- U/P urea ratio(mg.dl-1/ mg.dl-1)(day 0 to day 3)
- fractional excretion of urea (%),(day 0 to day 3)