Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fear
- Sponsor
- Duke University
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- Neurophysiological activity
- Status
- Recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.
The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years of age or older
- •Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
- •Willing to provide informed consent and participate in the study
- •Ability to read and write English fluently
Exclusion Criteria
- •Unwilling to provide informed consent
- •Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
- •Pregnant women
- •Participants with active psychosis
- •Participants with suicidal ideation
- •Participants with substance abuse issues
Outcomes
Primary Outcomes
Neurophysiological activity
Time Frame: during the intervention/behavioral tasks with and without stimulation
Neurophysiological activity will be measured in Hz
Physiological change - heart rate variability
Time Frame: during the intervention/behavioral tasks with and without stimulation
heart rate variability will be measured in milliseconds.
Physiological change - skin conductance
Time Frame: during the intervention/behavioral tasks with and without stimulation
Skin conductance will be measured in microSiemens.
Physiological change - eye-blinks
Time Frame: during the intervention/behavioral tasks with and without stimulation
Eye blinks will be measured using an eye tracking device and will be measure in blinks per second.