Chronic effects of capsinoids ingestion on energy expenditure by brown adipose tissue in humans
- Conditions
- Healthy male volunteers
- Registration Number
- JPRN-UMIN000006810
- Lead Sponsor
- Tenshi College, School of Nursing and Nutrition, Department of Nutrition
- Brief Summary
Whole-body energy expenditure (EE) at 27C and 19C was measured in 10 healthy male subjects, before and 6 weeks after daily ingestion of capsinoids (9mg/day) or placebo. Before the ingestion, EE at 19C was slightly and insignificantly higher than that at 27C. However, after 6-week ingestion of either capsinoids or placebo EE at 19C was significantly higher than that at 27C, while EE at 27C was similar to that before the ingestion. Cold-induced thermogenesis (CIT), calculated from the difference in EE at 19C and 27C, was about 205.1 kcal/day after capsinoids ingestion, which was much higher that that before the ingestion (20.6 kcal/day). After placebo ingestion, CIT was 81.0 kcal/day, being almost equal to that before the ingestion (64.8 kcal/day), but significantly lower than that after capsinoids ingestion. No notable effect of capsinoids ingestion was found in body weight and body fat content. Considering that CIT is an index of brown adipose tissue (BAT) activity, the present results suggest that daily ingestion of capsinoids may recruit BAT in humans. 1. Experimental Biology 2012, April 23, 2012, San Diego, USA, Minisymposium, Abstract No.252.4
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 20
Not provided
Body mass index >=30
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Whole body energy expenditure assessed from respiratory gas analysis
- Secondary Outcome Measures
Name Time Method Respiratory quotient Skin temperature Body fat content