Investigating the effects of modified ultrafiltration on rotational thromboelastometry (ROTEM) and inflammatory cytokine response in patients under cardiopulmonary bypass surgery
Phase 3
- Conditions
- coronary artery disease.Atherosclerotic heart disease
- Registration Number
- IRCT2017042127617N3
- Lead Sponsor
- Vice Chancellor for Research, Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
patients candidated for cardiopulmonary bypass surgery; cardiopulmonary bypass time from 50 to 120 minutes; number of grafts 3 or 4,/
Exclusion criteria: patient denying to participate in the study; cardiac conditions/comorbidities affecting the
recovery after sternotomy; previous history of cardiac arrest; use of defibrilator during operation
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ROTEM parameters. Timepoint: After declamp, after separation from pump, 24 hours after operation. Method of measurement: Plasma analysis using ROTEM machine.;Hemoglobin and hematocrit. Timepoint: Before and after operation. Method of measurement: Biochemical analysis.;Inflammatory cytokine response (IL-6, -8, -10 and TNF-alpha). Timepoint: After declamp, after separation from pump, 24 hours after operation. Method of measurement: Plasma analysis using ELISA technique.
- Secondary Outcome Measures
Name Time Method